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In 2000, a little more than 33,000 Cubans stopped smoking, while in 2002 that jumped to over 155,000

For MVMR, in addition to the multivariable extension of the MR PRESSO global test, we used the multivariable extension of the MR Lasso method, which applies lasso-type penalization to the direct effects of the instruments on the outcome disease: the so-called post-lasso estimate is obtained by performing MR IVW using only those instruments identified as valid instruments (tuning parameter specified at default heterogeneity stopping rule) 89

The 2.5-liter achieves up to 33 mpg and a range of more than 600 miles on a single tank

However, those declines have been accelerating in recent years

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