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Widespread upregulation of nAChRs, likely related to receptor desensitization from nicotine exposure, has been observed among smokers [70, 71] and, conversely, smoking cessation associated with decreases in regional nAChR densities [72]

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"Above and beyond the people who quit smoking entirely represented in that over 50% decrease but even people who are smoking less on a daily basis, they are then reducing the risk of a lot of those negative health outcomes." ADVERTISEMENT The decline in cigarette smoking was significant among 18- to 24-year-olds, going from 23% of that age group being regular smokers to 7.4%, according to the report