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Mendelian randomization (MR) study uses genetic variants as instrumental variables to explore the effects of exposures on outcomes, reducing potential biases caused by confounding and reverse causation 14

Use of e-cigarettes has grown significantly over the past decade, especially among high school students and young adults, though the short- and long-term health effects of e-cigarettes are unknown

As noted above, Mendelian randomization studies report comparable risk reductions to observational studies 13,14,15