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Chronic smokers may have nicotine accumulate in fatty tissues, which can release nicotine back into the bloodstream over time, prolonging its presence in the body

For example, extraction and purification of nicotine from the tobacco plant requires a large amount of water and generates non-recyclable halogenated waste and pollution 1,2,5

Supporting the relevance of these findings, long-term exposure to e-cigarette aerosols consistently 42 leads to a decrease in the expression of DNA repair genes ( ERCC1 , XPC , OGG1 , ATM ) in vitro 36 , in mice 43 , and in e-cigarette users 68

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