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(This is a common practical problem when conducting meta-analyses.) The varying definitions of disease progression include severity of disease based on clinical manifestations, development to more severe conditions, increasing oxygen supplements, prolonged viral shredding, organ injuries, ICU admission, and death

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What's more, the researchers note that their large study likely underestimates the risks, given that smokers are less likely to live long enough to have even entered the study

However, they may also be more expensive and their health impacts are not yet fully understood

By DEAN LIDDELL