smoking marijuana can be as unhealthy as smoking cigarettes and Oral Effects of Tobacco Use So smoking skunk causes psychosis,

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The scientists found that the brains response to nicotine triggers the activity of cannabinoid receptors and increased levels of an important enzyme called cPLA2, which is involved in activating these receptors

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The experiments in rodents further suggest that nicotine administration throughout fear acquisition and extinction delayed safety learning and inhibition of conditioned threat responses during extinction training 18