The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications
Ferulic acid protects against oxidative stress-associated apoptosis in rats by inhibiting the mRNA expression of intercellular adhesion molecule-1 in rats [28,108]
doi: 10.1016/j.arr.2023.102066 49 ImaiHMatsuokaMKumagaiTSakamotoTKoumuraT
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Clinical Data Support: Presence of clinical trial reports demonstrating improvements in skin brightness and reduction in melanin density
It is hypothesised that these mechanisms occur in a spiralling, progressive way, toppling the hosts homeostatic equilibrium (59)