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Dysregulated pain processing is increasingly recognized as a potential barrier to smoking cessation [88, 89] and emerging evidence suggests bidirectional relations between pain and smoking behaviors [90, 91]

This was not the first time that Sharon had resorted to extreme measures to dissuade her husband from engaging in his bad habits

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A separate study showed a significant impact of e-cigarette aerosol on TEER following 10 days of exposure (compared to 2448 h in the Haswell study) that was similar to cigarette smoke, suggesting that longer-term exposure to e-cigarette aerosol may have an impact on epithelial barrier function [24]