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We note that these are first promising proof-of-principal data that need to be confirmed in future studies, importantly these studies need to assess the impact of IRAK4 inhibitor treatment on pathological tissue remodeling and damage, e.g

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Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages

Levelling-off of the risk of lung and bladder cancer in heavy smokers: an analysis based on multicentric case-control studies and a metabolic interpretation

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