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The low bioavailability of NO is at least in part the result of uncoupling of eNOS, which inhibits production of NO, and the scavenging of NO by the superoxide radical leading to the formation of the highly reactive peroxynitrite (ONOO-) [5, 72]

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doi:10.1002/da.20018

FIGURE 2 CSS Exposure Enhances the OVA-Induced Allergic Responses in the Nasal RM As CS may influence airway allergic responses, we next examined allergic responses in the OVA-sensitized allergic rhinitis mice with or without CSS exposure