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Over time, this can cause chronic obstructive pulmonary disease (COPD, a long-term lung disease that makes it hard to breathe), which includes emphysema and chronic bronchitis

However, the neurobiological bases for these sex differences have eluded researchers, making it difficult to design gender-specific smoking cessation treatments

Though cannabis may have played a minor role in Cashs personal saga, its clear that his deeper legacy lies in his ability to turn pain into poetry and performance

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