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In The Sleeping Cardinal , Holmes uses tongs to lift a burning coal from the fireplace and uses it to light his pipe: an act borrowed from the short story "The Adventure of the Copper Beeches"

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[94] Thus, the negative effects of increased COHb levels are much more striking than those of COMb, effectively reducing both the O2 supply to the tissues and the O2 uptake of working muscles

This and other results suggest that the mechanism for the disturbance to sleep patterns and molecular rhythms associated with smoking is that SIRT1 regulates BMAL1, and the smoking-related decrease of SIRT1 therefore damages BMAL1 in mice and human smokers

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