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Urgent, prompt attention can improve the outcome greatly

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Scollo and colleagues conducted three literature reviews (Scollo & Lal, 2005, 2008

The MR approach infers causal relationships between exposures and outcomes, overcoming the limitations of observational studies, founded on three core assumptions: strong association between instrumental variables and the exposure, no association between instrumental variables and confounding factors, and instrumental variables influencing the outcome solely through their association with the exposure

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Mealing NM, Banks E, Jorm LR, Steel DG, Clements MS, Rogers KD