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One of the eight studies challenges the reliability of the tobacco companys claim that, compared with continuing smokers, American smokers who switched to IQOS saw improvements on two dozen biomarkers narrow measures of organ function that often stand in as surrogates for overall health

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Med Princ Pract 25(Suppl 2):4159 Crowley-Weber CL, Dvorakova K, Crowley C, Bernstein H, Bernstein C, Garewal H, Payne CM (2003) Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis

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