The system-wide physiologic effects of nicotine are mediated by its ability to affect the release and metabolism of neurotransmitters, and include increased blood pressure, increased pulse rate, increased free fatty acids in the plasma, mobilization of blood sugar, and increased concentrations of catecholamines in the blood [3439]
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Additional observations support that exposure to e-liquid induces not only oxidative stress but also decreases total antioxidant capacity, leading to even greater systemic oxidative stress [40]
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The ISO TNCO levels fall within those maximum levels and therefore comply with the law
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