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Vype ePen3 has a different design to the ePen product used in an earlier study (Margham et al., 2016) and is shown schematically in Figure 1

This heavy-gauge brass vessel exemplifies early American tobacco advertising, combining functional saloon ware with promotional branding

This effect is often persistent and last several weeks, with factors such as pain or cravings potentially exacerbating symptoms

Conversely, the windows should drop slightly on opening

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Non-smokers were defined as respondents who stated at the time of enrolment that they had never smoked or had not smoked in the previous five years, as well as had not smoked more than 100 cigarettes in their lifetime 28,29