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Marijuana smokers, however, did not have higher levels of acrolein in their bodies

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These findings collectively elucidate that heavy smoking is associated with systemic oxidative stress, inflammation, and vascular dysfunction

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Among various ingredients in cigarette smoke, TNSAs are known as the responsible compounds for the formation of DNA adducts (81)

However, age-dependent deregulation of the immune system and immunosenescence can decrease the removal of senescent cells by immune cells [12]