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The main toxic culprit in holly leaves and berries is a group of chemicals called saponins

online Cadham, Christopher J., et al

And isnt this what we all secretly want (but rarely openly admit to)

Figure 3 In 2020, British Columbia (BC) became the first province to announce that it would implement a formal lung cancer screening program (for high-risk individuals aged 5574 years who are currently or have previously smoked and have a 20-pack-year smoking history) (70)