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In cohort studies, ALS confirmation was done through national registries, and the follow-up period ranged from 7 to 28 years

Additionally, the nicotine in chewing tobacco constricts blood vessels, impairing blood flow and potentially leading to tissue damage

Committee on Substance, and Prevention, Nicotine and tobacco as substances of abuse in children and adolescents

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While this falls short of the FDAs designation of being approved as generally safe, it allows ZYN to continue selling its three- and six-milligram nicotine pouches in 10 different flavors, including spearmint, citrus, coffee, cinnamon and menthol