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In conclusion, the evidence suggests that IST-induced covalent oligomerization of p62 to activate Nrf2 may represent a promising avenue for the treatment of RA [132]

It reached Phase II clinical trials for postoperative ileus (a gut-recovery condition) and was discontinued after the trial did not show efficacy

Delayed-release metformin was about half as bioavailable as immediate-release or extended-release metformin, but was about 40% more potent than extended-release metformin in reducing fasting plasma glucose

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