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The major category factors include medications, diet, inflammation, autoimmune conditions, gut health, and genetics: Non-steroidal anti-inflammatory drugs (NSAIDs): Aspirin, ibuprofen, and other NSAIDs can interfere with DAO function

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What neither position disputes is the core finding that makes today's hearing clinically significant: across all four compounds on Day 1's agenda, there are no large, controlled, randomized human trials establishing safety or efficacy for the proposed injectable routes