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Adv Cancer Res (2014) 122:281320

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To determine differences between GLP-1R WT and V229A beta cell downstream signalling, cAMP and insulin secretion responses to exendin-4 were investigated in INS-1 832/3 SNAP/FLAG-hGLP-1R WT and V229A

In addition to GLP-1R, the peptide itself appears to be important for this interaction, as the increased levels of GLP-1 after DPP-IV inhibition (with sitagliptin) reduce nicotine consumption in male mice (Tuesta et al., 2017)