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Lean mass loss is clinically relevant because it reduces physical function and resting metabolic rate, potentially amplifying compensatory responses and increasing susceptibility to weight regain ( GLP-1RAs are not designed to exert anabolic effects on skeletal muscle

Concomitant diseases of patients in this trial included, but were not limited to, heart failure (12%), history of ischemic stroke (8%) and history of a MI (36%)

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Liddelow SA, et al