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Focusing on the type of exposure, most of the studies that reported increased risk of lung cancer mainly assessed the effect of acute exposure to e-cigarettes (Figure 3)

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These included four RCTs,478, 483, 484, 485 two post-hoc analyses of previous RCTs,245, 486 and two cohort studies.487, 488 The studies were primarily focused on evaluation of dual or poly-use of conventional cigarettes and other tobacco products (e-cigarettes, waterpipes, cigars)

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The highly popular Juul device resembles an elongated USB drive and utilizes pre-packaged pods containing a proprietary e-liquid with numerous available flavors, including fruit flavor, crme and mint

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