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High-dimensional, single-cell characterization of the brains immune compartment

Isotretinoin is fat-soluble and metabolized almost entirely by the liver through a family of enzymes called cytochrome P450

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Do not drink alcohol or smoke for at least 24 hours

Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), changes in glutaminolysis that deplete KG, and alterations in fumarate hydratase and succinate dehydrogenase that inhibit KGDD activity 11