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Compounded versions of semaglutide, the active ingredient in approved diabetes and obesity drugs Ozempic and Wegovy, have been associated with at least 100 hospitalizations and 10 deaths, the chief executive of Ozempic maker Novo Nordisk warned Wednesday

Higher starting weights typically correlate with higher absolute weight loss

"In patients with obesity who were prescribed semaglutide or liraglutide, we found that long-term weight reduction varied significantly based on the medication's active agent, treatment indication, dosage and persistence with the medication," said Hamlet Gasoyan, lead author of the study, in a statement

The Problem with Muscle Loss Muscle tissue is metabolically expensive

doi: 10.1038/s41420-021-00579-w

Finally, because of the supraphysiological levels of GLP-1 activity, GLP-1 RAs may delay gastric emptying resulting in a decrease in postprandial glucose levels and induce satiety, which will decrease food intake (22)