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A series of studies went on to show that a single oral administration of CBD (300 mg) is able to reduce the acute anxiety caused by public speaking in a total of 157 volunteers (some of which received placebo or other CBD doses) [41,42,43]

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They then used chemical antagonists to inactivate a specific nicotine receptor called alpha-7 in the aversion network, which reduced the effects of aversive nicotine on neural activity