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A large biopsy-based study reported that a smoking history of 10 pack-years was significantly associated with advanced fibrosis (adjusted OR 1.63

Doses of nicotine that are tolerated by adult smokers during treatment can cause serious poisoning symptoms in young children and can cause fatal

And tobacco companies discovered long ago that adding ammonia to cigarette tobacco created a form of nicotine that was more desirable, and more addictive to the user

Chronic exposure to tobacco smoke also triggers epithelial-mesenchymal transition (EMT) through signaling pathways such as Wnt/-catenin and MAPK, transforming normal bladder cells into invasive and metastatic cancer cells

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