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Since the microbiome contributes to systemic immunity and can metabolise certain drugs, this may represent an indirect mechanism affecting both host susceptibility to TB and the bioavailability of orally administered anti-TB agents (Fan et al., 2023

Specifically, nicotine dependence includes: Tolerance to nicotine by needing more and more of the drug to feel normal as well as the absence of nausea and dizziness with repeated use

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The European Journal of Public Health

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The team found that nicotine directly activates a protein called AMPK in the intestines