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However, the authors of the Lancet paper say: "We believe that there is now enough evidence to inform people that using cannabis could increase their risk of developing a psychotic illness later in life."

Cigarettes contain about 8 to 14 milligrams of nicotine, with smokers usually absorbing 0.5 to 2.5 milligrams of that total, Reynolds claims

therefore, no additional ethical approval was required for the present analysis

That proportion has since fallen to 17.2% in 2015