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Similar content being viewed by others 1 Introduction Since 2000, the Surgeon General of the United States has issued eleven Medical advice reports are being used to promote worldwide awareness of crucial public health issues

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When caffeine is added to the equation, the likelihood (and severity) of adverse effects is multiplied, due most likely to the fact that PPA can produce dramatic increases in blood caffeine levels.14 Cases have been reported where individuals suffered manic psychosis after ingesting caffeine and PPA.15 The effects of the widely consumed drugs caffeine and phenylpropanolamine are mediated through activation of the central and sympathetic nervous systems

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