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An earlier study identified an association between SHS exposure and lung cancer in brachycephalic (short-nosed) dogs 48 , while another study found DNA damage in the oropharyngeal tissues of dogs exposed to SHS 49 suggesting a potential anatomical predisposition linked to muzzle morphology

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[13] In response to these studies and their perceived threat to the tobacco industry's future profitability, tobacco companies experimented with new modifications to the cigarette design