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Refinement which refers to methods that alleviate or minimize potential pain, suffering or distress, enhance animal welfare for the animals used, and use non-invasive techniques

The jury added a rider to their verdict of Misadventure, to the effect that the management should exercise a stricter supervision over the bathers and should never permit them to be left unattended in the hot room

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The health risks associated with products like Zyn pouches are not fully understood because theyre relatively new

Pre-publication history The pre-publication history for this paper can be accessed here: Acknowledgements This project was funded by the Instituto de Salud Carlos III (grants FIS PI020261 & PI081436) and the Thematic Network of Cooperative Research on Cancer (grant RD06/0020/0089), Government of Spain, and the Ministry of Universities and Research (grant 2009SGR192), Government of Catalonia

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