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examined nicotine toxicity on the ultrastructure of the testis of mice and showed that administration of nicotine for 3 months resulted in thickening of Tunica Propria, increased collagen fibers, loss of intercellular connections in Sertoli cells, and chromatin deficiency [37]

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The agreement explicitly banned paid product placement, outdoor advertising, tobacco sponsorship of sporting events, and advertising and marketing practices that targeted individuals under 18