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In severe cases, even reducing 25 events per hour may still leave a patient with significant OSA

The cheeks flatten, the lower eyelids hollow and develop visible bags or shadows, and the overall face looks tired or aged in a way that can feel disproportionate to the patients actual age

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[55] Additionally, by blockading FOXO transcription factors and NF-B, the drug modulates SASP and upregulates anti-apoptotic proteins (such as Bcl-2), potentially delaying tissue degeneration and offering anti-aging benefits

Additionally, cognitive deficiency was frequently observed, e.g., problems with working memory, concentration, collecting visual memories, and general cognitive abilities