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Abstract Cigarette smoking (CS) regulates both innate and adaptive immunity and causes numerous diseases, including cardiovascular, respiratory, and autoimmune diseases, allergies, cancers, and transplant rejection

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TGF-/Smad Pathway The TGF-/Smad pathway is a central regulator of fibrosis, EMT, and senescence-associated tissue remodeling in chronic lung diseases [104,105,106]

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