The occurrence of such mutations in patients was evaluated from the North American Pancreatitis Study cohort II and it was found that a genetic variant, CTRC Variant G60G (c.180T), acted as a disease modifier, promoting progression of RAP to CP, particularly in the smoking population (60)
However, a recent review, published in The Lancet Oncology, found that most countries havent put these measures in place
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Cancer Causes and Control, 22(5):753-763
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