Cardiovascular effects One of the few things scientists know for sure about marijuana and cardiovascular health is that people with established heart disease who are under stress develop chest pain more quickly if they have been smoking marijuana than they would have otherwise
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Mechanistically, nicotine activates AMPK2 in adipocytes, which phosphorylates MAP kinase phosphatase-1 (MKP1) at serine 334, resulting its proteasome-dependent degradation (19)
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If legal, more doped-up people may go behind the wheel and put others in harms way