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25 started from the initial assumption that nicotine administration in experimental animals increases cardiac work, blood flow, and oxygen consumption, but at the same time, tobacco smoke contains carbon monoxide, thus possibly reducing tissue oxygenation

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The panel rejected the argument that scientific publications presented as evidence in dispute settlement proceedings can only be validly considered by a panel if the complete underlying research data is also made available.[17] Because public health authorities rely on scientific publications to support their actions, this evidentiary finding is important

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