Furthermore, a key limitation of oral administration is the off-target effect, where most of the drugs may act on peripheral organs before they can reach the CNS
Then we optimized the enzymes structure through a method called protein engineering so that it efficiently converts precursor to 3MH, without generating off-target sulfur compounds
Nature 540 , 139143 (2016)
This shift reduces the overall metabolic drain on the body, freeing up energy reserves that the patient can finally use for daily living and physical recovery
Similarly, the European Medicines Agency (EMA) has published reflections on the qualification of novel methodologies, providing a conceptual framework for their evaluation (223)
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