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Ozempic doesnt typically lose its mechanism of action, but its visible effect on the scale slows over time as your body adapts metabolically
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3-12 months) does not influence food consumption, body weight or mean life span of mice
Nat Neurosci 6 : 10581063
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Therefore, it remains unclear whether the reduction of steatosis observed in animal and human trials in response to treatment with GLP-1R agonists results from direct activation of hepatic GLP-1R or the indirect impact such as weight loss, increased insulin sensitivity, brain-liver signals such as brain leptin 51 , or other hormonal signals that these agonists might trigger 14
