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In any case, discussions of whether the water or the tobacco temperature reduces smoke toxicant content from some maximal level may be made moot by the fact that, in a single use episode with water in the waterpipe and a relatively low tobacco temperature, a waterpipe produces an average of 90,000 ml of smoke that, relative to a single cigarette, contains about 8 times the CO (Table 2), 36 times the tar (see Table 2), and more than 50 times the quantity of some carcinogenic polycyclic aromatic hydrocarbons, 53 as well as heavy metals such as lead and cobalt

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She said this change in the microbial landscape accompanied by higher levels of proteins in vapers mouths that signaled the immune system was on standby to activate and produce inflammation exponentially increases the likelihood for disease

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