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For those who are both, I'd say the main advantage here is that unlike many Lord-of-the-Ring-ish, pipe-shaped objects out there, this is definitely a pipe, made by people who make pipes for a living

Combination with varenicline has been studied and may be used selectively, but requires close monitoring for side effects and is decided case-by-case

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The authors have completed and submitted an ICMJE form for disclosure of potential conflicts of interest and they declare that they have no competing interests, financial or otherwise, related to the current work