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The appropriate comparison depends on the receptor model being studied

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Para ello, acta como un agonista, una sustancia que imita a la hormona natural mediante la unin a los mismos receptores celulares en el cerebro y produce una respuesta similar o aumentada en el organismo, lo que incluye mayor liberacin de insulina, disminucin del apetito y digestin lenta

Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde A-M, Sabatine MS

Large prospective longitudinal studies, including clinical trials, are needed to comprehensively explore the regulatory impact of leptin on bone and its potential implications for fracture risk (110, Table 1)

Tjarks et al