Bayer has filed to modify the label for its chronic kidney disease (CKD) Kerendia to include people with type 1 diabetes, extending its current use in type 2 forms of the disease
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However, their use in the perioperative period surrounding major surgeries, like total joint arthroplasty (TJA), remains an area of growing interest and concern
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A review of pivotal clinical trials for semaglutide (STEP, SUSTAIN), dulaglutide (REWIND), liraglutide (LEADER), and tirzepatide (SURPASS, SURMOUNT) does not identify muscle cramps as occurring at significantly higher rates compared to placebo groups
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