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Consequences of Tobacco Use Fifty percent of smokers die of a smoking-related disease, and the life expectancy of one in four smokers is reduced by as much as 15-20 years [5]

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At low concentrations, it is a weak inducer of CYP3A4, but at therapeutic levels shows inhibitory properties, suggesting the potential for both auto-induction and inhibition depending on the concentration (Howlader et al., 2022

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