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These changes need to happen gradually

If side effects persist and remain intolerable despite extended up-titration, a lower maintenance dose may be considered to support adherence and reduce the risk of treatment discontinuation [66]

| Concentration | BAC Water | Doses at 1.0mg | Doses at 2.4mg | |---------------|-----------|----------------|----------------| | 5mg/mL | 2.0mL | 10 doses | ~4 doses | | 2.5mg/mL | 4.0mL | 10 doses | ~4 doses | **Best practice:** 2.0mL BAC water gives a clean 5mg/mL concentration

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It is still uncertain whether these risks are caused by direct mechanisms such as changes in blood flow or are influenced by confounding factors like preexisting vascular conditions