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This theoretical expectation of at least one of the relative and absolute smoking-mortality associations changing over time is supported by recent longitudinal studies of the tobacco epidemic that report increasing relative rates of mortality in current-smokers compared to never-smokers over several decades 7,8,9,10

Human coronary endothelial cells treated with nicotine showed increased expression of ACEI, nitric oxide synthase, and vascular cell adhesion molecule-1 (VCAM1) [113]

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