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Bupropion is likely to exert its pharmacological effects by weakly inhibiting the reuptake of both dopamine and norepinephrine, therefore prolonging their duration of action within the neuronal synapse and their downstream effects

Breathing secondhand smoke (SHS) causes heart disease and lung cancer in adults and increased risks for sudden infant death syndrome, acute respiratory infections, middle-ear disease, worsened asthma, respiratory symptoms, and slowed lung growth in children

Except for smokers, this may pose a serious threat to more vulnerable members, such as children and adolescents, who may be persuaded to start using e-cigarettes, become addicted to nicotine, and eventually start smoking under unproven safety assumptions

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In short, it is the one with the worst of all the various shortcomings of the Bohem series