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And among these substances, there is a particularly prominent one, nicotine, which apart from being carcinogenic and able to cause immediate toxic effects (rise in cardiac frequency and blood pressure, and even acute intoxication syndromes), is all by itself responsible for cigarette dependency and the difficulty to quit smoking

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Instead, the note referenced broad-based strength in the company's global footprint, where consistent performance in both developed and emerging markets has helped support top-line growth

Screening the documents qualitatively in batches of 50 to 100 helped refine and narrow the search allowing us to collect documents that would help construct a history and provide context for the information that was coming forth

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